Electrostatic potential surface for M107
This anaesthetic has more than one structural configuration. An example low energy conformer is shown.
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Surface view shows the electrostatic potential of the conformer mapped onto the solvent excluded surface, based on a probe of radius 1.4Å. Regions of negative potential are shown in red, positive in blue.
 
Structure Details
Structural Formula CH3-CH2-O-CH2-CH3
Molecular Formula C4H10O
Chemical Group Ether
Anaesthetic Type Inhalational: Conventional Agent
Chiral Structure No
molfield.org ID M107
CAS Number 60-29-7
ChEMBL (External Link) CHEMBL16264
ChEBI (External Link) CHEBI:35702
Drug Bank (External Link) -
ChemSpider (External Link) 3168
PubChem (External Link) 3283
Chemicalize.org (External Link) CAS No 60-29-7
SMILES String CCOCC
Molecular Weight (g.mol-1) 74.122
SynonymsEthyl ether
In Vivo Activity Data
Immobility: MAC Rat (atm)0.032Zhang Y, Eger EI II, Dutton RC & Sonner JM. Anesth Analg 2000;91:462-45
Immobility: MAC Dog (atm)0.0304 ± 0.0053 (n=10)Eger EI II, Brandstater B, Saidman LJ, et al. Anesthesiology 1965;26:771-7
Immobility: MAC Human (atm)0.0192Saidman LJ, Eger EI II, Munson ES, et al. Anesthesiology 1967; 28:994-1002
Physical Properties
Olive Oil / Gas Partition Coeff. at 37°C65Eger EI II, Brandstater B, Saidman LJ, et al. Anesthesiology 1965;26:771-7
Blood / Gas Partition Coeff. at 37°C12Steward A, Allott PR, Cowles AL & Mapleson WW. Br J Anaesth 1973;45:282-93
Water / Gas Partition Coeff. at 37°C13Steward A, Allott PR, Cowles AL & Mapleson WW. Br J Anaesth 1973;45:282-93
Calculated Molecular Properties
van der Waals Volume 87 Å3 
van der Waals Surface Area 137 Å2 
Solvent Accessible Volume 359 Å3(based on a 1.4Å probe)
Solvent Accessible Surface Area 273 Å2(based on a 1.4Å probe)
All values are mean ± SD, except data labelled with † which are mean ± SEM. Use of this web site assumes acceptance of our Copyright & Licence conditions.
Database Version: 1.09.9     Last Updated: 21st February 2014