Electrostatic potential surface for M159
This anaesthetic exists as resonance structures. An example contributing structure is shown.
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Surface view shows the electrostatic potential of the conformer mapped on to its solvent excluded surface (based on a 1.4Å radius probe). Regions of negative potential are shown in red, positive in blue.
 
Structure Details
Structural Formula N≡N+-O- ⇔ N-=N+=O
Molecular Formula N2O
Chemical Group Other
Anaesthetic Type Inhalational: Conventional Agent
Chiral Structure No
molfield.org ID M159
CAS Number 10024-97-2
ChEMBL (External Link) CHEMBL1234579
ChEBI (External Link) CHEBI:17045
Drug Bank (External Link) -
ChemSpider (External Link) 923
PubChem (External Link) 948
Chemicalize.org (External Link) CAS No 10024-97-2
SMILES String [N][N][O]
Molecular Weight (g.mol-1) 44.0129
SynonymsDinitrogen monoxide
In Vivo Activity Data
Immobility: MAC Rat (atm)1.55 ± 0.16 (n=17)Russell GB, Graybeal JM. Anesth Analg 1992;75:995-9
Immobility: MAC Dog (atm)1.88 ± 0.35 (n=5)Eger EI II, Brandstater B, Saidman LJ, et al. Anesthesiology 1965;26:771-7
Immobility: MAC Human (atm)1.04 ± 0.26 (n=6)Hornbein TF, Eger EI II, Winter PM, et al. Anesth Analg 1982;61:553-6
Physical Properties
Saline / Gas Partition Coeff. at 37°C0.45Kozam RL, Landau SM, Cubina JM, et al. J Appl Physiol 1970;29:593-7
Olive Oil / Gas Partition Coeff. at 37°C1.4Meyer KH, Gottlieb-Billroth H. Z Physiol Chem 1920;112:55-79
Blood / Gas Partition Coeff. at 37°C0.47Steward A, Allott PR, Cowles AL & Mapleson WW. Br J Anaesth 1973;45:282-93
Water / Gas Partition Coeff. at 37°C0.47Steward A, Allott PR, Cowles AL & Mapleson WW. Br J Anaesth 1973;45:282-93
Calculated Molecular Properties
van der Waals Volume 30 Å3 
van der Waals Surface Area 53 Å2 
Solvent Accessible Volume 167 Å3(based on a 1.4Å probe)
Solvent Accessible Surface Area 152 Å2(based on a 1.4Å probe)
All values are mean ± SD, except data labelled with † which are mean ± SEM. Use of this web site assumes acceptance of our Copyright & Licence conditions.
Database Version: 1.09.9     Last Updated: 21st February 2014